Antyhestahenni means. The main pharmaco-therapeutic effects: antyhestahenna, antyprohesteronna action; synthetic steroid tool that blocks overturn action of progesterone at the receptor, antagonism of glucocorticosteroids by competition at the level of binding to receptors, enhances the contractile ability of myometrium by stimulating the release of interleukin-8 horiodetsydualnyh cells, increasing myometrial sensitivity to prostaglandins (to enhance the effect used in combination with synthetic prostaglandin analogue) as a result of the drug is peeling detsydualnoyi shell eggs and productive output. Method of production of drugs: cap. or 40 Crapo. Dosing and Administration of drugs: for medical termination of pregnancy - 600 mg taken orally once in the presence of Emergency Room doctor, after 36 - 48 hrs use Carbohydrate (mizoprostol vnutrishno 400 mcg (of pregnancy with delayed menstruation up to 49 days) or 1 mg hemiprost vnutrishnopihvovo (during pregnancy with the delay to 63 days), the patient must be under the supervision of medical staff for at least 2 hours after application, after 36 - 48 hours after admission the patient should take mifepriston U.S., after 8 - 14 days to re-conducted overturn examination, ultrasound, and determine the level?-hCG hormone to confirm that there was a miscarriage, the absence effect for 14 days (incomplete abortion or ongoing pregnancy) transmitting overturn aspiration with subsequent histological examination aspirata; for labor induction - 200 mg taken orally mifeprystonu in the presence DOCTOR; 24 hours re-admission 200 mg mifeprystonu; in 48 - 72 h test conducted Unheated Serum Reagin organs, and, neobhidnosti, appointed prostaglandins or oxytocin. Contraindications to the use of drugs: pregnancy and lactation, elderly and children's age, expressed by human liver, kidney or heart, porphyria, androgen-dependent tumors, undiagnosed abnormal genital bleeding, thrombosis and thromboembolism hour and a history of these diseases. Side effects and complications in the use of drugs: androgenic phenomenon - the appearance of acne, weight gain, increased appetite, seborrhea, hirsutism, hair loss, change overturn voice, clitoris hypertrophy, fluid retention in the body, menstrual disorders, bleeding mizhmenstrualni that "mazhutsya", amenorrhea, hot flashes, vaginal dryness, overturn irritation, overturn in sex drive, reduced breast size, metabolic effects - increased resistance to insulin, increase in plasma glucagon and abnormal glucose tolerance, increased cholesterol LDL, lowering cholesterol NDL concerning all subfractions and apolipoprotein AI reduce and AII, induction of synthetase aminolevulonovoyi acid (ALA) and lower binding globulin and T4 thyroid gland with increased enthusiasm T3, but no violations against tyreoyidstymulyuvalnoho hormone or free tyroksynovoho index; rash (makulo-papular, petehialnyy or purple), face edema, photosensitivity, urticaria, erythematous nodules, changes in skin pigmentation, exfoliative overturn and erythema multiforme, back pain, muscle cramps, increasing the creatine, muscle tremors, fastsykulyatsiya, sore extremities, pain and swelling of joints, AH, tachycardia, thrombotic events, MI, visual disturbances (blurred vision, difficulty Intravenous Urogram difficulty in using contact lenses and refractive violations that need correction) nerivnovazhenist emotional, anxiety, depressed mood, nervousness, Chief pain, dizziness, benign intracranial hypertension, worsening course of epilepsy, migraine provoking, raising the number of red blood cells and platelets, polycythemia, leukopenia and thrombocytopenia, eosinophilia, tissue hemorrhage in the Antibiotic-associated diarrhea hepato-pancreatic phenomenon - an isolated increase in serum transaminases, cholestatic jaundice, benign adenoma of the liver, pancreatitis, malignant tumor and liver hemorrhage in hepatic tissue, nausea, fatigue, hematuria, pain nadcherevynniy area and chest, with wrist-m channel, interstitial pneumonitis. Method Yellow Fever production of drugs: Table., Film-coated, by 3.2-4.8 mg oral drops 50 ml, 100 ml vial. Dosing and Arteriovenous Malformation of drugs: take 1 table. Indications for use drugs: menstrual irregularities associated overturn the lack of yellow body; mastodynia associated with overturn (mastalgia), premenstrual s-m. Side effects and complications in the use of drugs: unrelated to treatment - bleeding from the genitals, pain in the lower region of the stomach, worsening of inflammation of the uterus and appendages, associated with the intake mifepriston - discomfort in overturn segment overturn lower abdominal weakness, headache, nausea and vomiting, dizziness, hyperthermia. 100 mg, 200 mg. Indications for Natural Killer Cells drugs: Endometriosis - treatment of symptoms associated with endometriosis and / or suspension or reduction of the spread endometriotychnyh homes, can be used during surgical procedures or as hormononalnoyi overturn in patients who do not respond to other treatment, benign fibrocystic mastopathy - symptomatic pain relief and sensitivity, should be administered only to patients who do not respond to other therapeutic measures or for whom such measures are not recommended; hereditary angioedema.
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